Research Article

The Role of Using Micronized Purified Flavonoid Fraction After Rubber Band Ligation in Hemorrhoidal Disease: A Retrospective Analysis


  • Gürcan Şimşek
  • Alpaslan Şahin

Received Date: 19.02.2021 Accepted Date: 05.04.2021 Turk J Colorectal Dis 0;0(0):0-0 [e-Pub]


To investigate the effect of MPFF addition on the improvement in symptoms in patients who underwent LBL for HH.


Patients who underwent LBL for HH in our clinic in 2020 were retrospectively screened. Patients aged eighteen years or older treated by the same surgeon for stage II and III internal HH with LBL + MPFF or LBL alone were included in the study. The presence of bleeding, pain, itching, and prolapse complaints were questioned at the time of admission and on visit 1(7th day) and visit 2 (28th day). Also, LBL complications were recorded. All patients were asked to evaluate their general anal area comfort with a visual analog scale at admission and visit 1 and 2. The patients were divided into two groups: patients who received combined therapy and those who only had LBL.


The rate of bleeding in the first visit was significantly lower in the group given MPFF than the group that was not given (p <0.05). Persistence rates of pain, itching, and prolapse complaints in the first visit were lower in the group in which MPFF was used compared to the group without, but there was no statistical significance (p> 0.05). At the first and second visits, the anal region comfort score was significantly higher in the group using MPFF than in the group not using it (p <0.05). The complication rate was lower in the group using MPFF compared to the group not used. However, there was no statistical significance (p> 0.05).


The addition of MPFF to patients who undergo LBL provides the most common symptom, bleeding, to be controlled earlier. Combined therapy results in an improvement in general anal area comfort compared to LBL alone.

Keywords: Hemorrhoidal disease, anal bleeding, flavonoid, rubber band ligation